핵심 개념
Achieving microbiological cure in Mycobacterium avium patients significantly boosts survival rates.
초록
Patients with nontuberculous mycobacterial pulmonary disease caused by Mycobacterium avium complex (MAC) showed improved survival rates when achieving microbiological cure at the end of treatment. The study, conducted by Joong-Yub Kim, MD, and colleagues, focused on the impact of microbiological cure on long-term survival in 382 adult patients with NTM-PD. Key findings include the association between microbiological cure and reduced mortality, highlighting the importance of successful treatment outcomes in NTM-PD patients.
통계
Patients who achieved microbiological cure were significantly younger (63 years vs 68 years, P = .002) and had lower erythrocyte sedimentation rates (11.5 mm/h vs 23.5 mm/h, P < .001).
Those who achieved microbiological cure were less likely to use four or more drugs (8.5% vs 25.3%, P < .001) and had shorter treatment durations (18.4 months vs 22.3 months, P < .001).
Five-year survival rates were 89.4% for patients who achieved microbiological cure and 81.0% for those who did not.
인용구
"Given the importance of microbiological cure, patients who fail standard therapies should be included in ongoing clinical trials."
"The results highlight the importance of microbiological success at completion of treatment for NTM-PD patients."