This study investigates how the release of neuromodulators, specifically acetylcholine (ACh) and dopamine (DA), in the basolateral amygdala (BLA) contributes to the processing of emotionally salient vocalizations and the resulting behavioral responses in male and female mice.
The key findings are:
Playback of vocalizations associated with mating or restraint behaviors elicited distinct patterns of ACh and DA release in the BLA of male mice. Restraint vocalizations increased ACh release and decreased DA release, while mating vocalizations had the opposite effect.
In female mice, the estrous stage modulated the ACh response to mating vocalizations. Estrus females showed increased ACh release, which was associated with increased vigilance behaviors like flinching, compared to non-estrus females and males.
A single prior experience with mating or restraint behaviors was sufficient to shape the neurochemical and behavioral responses to the corresponding vocal stimuli. Mice without this prior experience did not exhibit the distinct patterns of ACh and DA release observed in experienced animals.
The results suggest that ACh and DA provide context- and state-dependent information to BLA neurons during the processing of emotionally salient vocalizations, which in turn modulates the behavioral responses of the listener. This highlights the importance of neuromodulatory inputs in shaping how the amygdala processes and responds to social communication signals.
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biorxiv.org
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by Ghasemahmad,... 게시일 www.biorxiv.org 07-04-2022
https://www.biorxiv.org/content/10.1101/2022.07.02.498564v5더 깊은 질문