Modeling Ion-Based Information Dynamics in Cells Using Cell-Reservoir Computing

Belangrijkste concepten

Ion gradients enable rapid cellular response to environmental perturbations through cytoskeleton-mediated information transmission.

Samenvatting

Cells utilize ion gradients for dynamic information processing, enabling rapid responses to environmental changes. The proposed model suggests that ions flow along pre-existing gradients through gated channels, altering cytoplasmic ion concentrations and triggering cellular responses. The cytoskeleton plays a crucial role in transmitting signals and orchestrating global cellular reactions. Experimental observations support the model's ability to disseminate responses to external perturbations rapidly. The Cell-Reservoir framework integrates bioelectrochemistry into a data-driven approach for modeling subcellular processes and decision-making.

Statistieken

Na+, K+, Cl−, Mg++, and Ca++
1/3 of a cell’s energy budget consumed by pumps
1011 bits of Shannon information in E coli
Conductance values ranging from 0.1-100 S/m for cytoskeletons

Citaten

"Information signals can potentially travel as solitons through the cytoskeleton network."
"Ion-based information processing at the membrane permits rapid and local responses to environmental perturbations."
"The Cell-Reservoir framework provides an algorithmic approach for modeling subcellular processes capable of learning directly from measurements."

Belangrijkste Inzichten Gedestilleerd Uit

Modeling non-genetic information dynamics in cells using reservoir computing

by Dipesh Nirau... om arxiv.org 03-18-2024

https://arxiv.org/pdf/2312.07977.pdf

Diepere vragen

How do ion gradients contribute to cellular adaptation beyond immediate responses

Ion gradients play a crucial role in cellular adaptation beyond immediate responses by enabling cells to sense and respond to changes in their environment. These gradients allow for rapid communication of environmental information into the cell through gated ion-specific membrane channels. The resulting changes in cytoplasmic ion concentrations can trigger local responses and orchestrate global or regional responses through wire-like ion fluxes along the cytoskeleton. This dynamic system permits cells to adapt quickly to changing environmental conditions, ensuring optimal evolutionary fitness.

What are potential limitations or criticisms of the proposed ion-based information dynamics model

One potential limitation of the proposed ion-based information dynamics model is its complexity and reliance on assumptions about the behavior of ions within the cell. The model assumes that ions flow along pre-existing concentration gradients through the cytoskeleton, transmitting information rapidly throughout the cell. However, this assumption may oversimplify the intricate processes involved in intracellular signaling and response mechanisms. Additionally, experimental validation of some aspects of this model may be challenging due to technical limitations in studying subcellular dynamics at such a detailed level.
Critics might argue that while ion gradients are important for cellular function, attributing all aspects of cellular adaptation solely to these gradients may overlook other critical factors influencing cellular behavior. Furthermore, there could be concerns about oversimplification or overgeneralization when applying this model across different cell types or biological contexts without considering specific variations and complexities inherent in each system.

How might understanding intracellular information transmission impact fields outside biophysics

Understanding intracellular information transmission has implications beyond biophysics and can impact various fields such as medicine, pharmacology, bioengineering, and artificial intelligence.

Medicine: Insights into how cells process external signals could lead to new therapeutic strategies targeting specific pathways involved in disease progression.
Pharmacology: Understanding how drugs interact with cellular signaling pathways could improve drug design and efficacy.
Bioengineering: Knowledge of intracellular communication networks could inspire novel biomimetic technologies for diverse applications.
Artificial Intelligence: Concepts from intracellular information processing might inform neural network architectures mimicking biological systems for improved learning algorithms.
Overall, a deeper understanding of intracellular information transmission has far-reaching implications across scientific disciplines beyond biophysics.