Belangrijkste concepten
Targeted surveillance of high-risk individuals can detect pancreatic cancer at an earlier, more treatable stage, leading to significantly improved survival outcomes compared to the general population.
Samenvatting
The study evaluated the effectiveness of targeted surveillance for pancreatic ductal adenocarcinoma (PDAC) in high-risk individuals. The researchers compared 26 high-risk individuals diagnosed with PDAC through the Cancer of the Pancreas Screening (CAPS) program to 1,504 matched control patients from the Surveillance, Epidemiology, and End Results (SEER) database.
Key findings:
- High-risk individuals were more likely to be diagnosed at an early stage (38.5% stage I vs 10.3% in controls) and had smaller tumors (median 2.5 cm vs 3.6 cm).
- Fewer high-risk individuals had distant metastases at diagnosis (26.9% vs 53.8% in controls).
- Median overall survival was significantly longer in high-risk individuals (61.7 months vs 8 months in controls).
- 5-year survival probability was much higher in the high-risk group (50% vs 9% in controls).
- High-risk individuals with screen-detected cancer had an even higher median survival of 144 months.
The study suggests that targeted surveillance of high-risk individuals, such as those with familial or genetic predispositions, can lead to earlier detection and improved clinical outcomes for pancreatic cancer patients.
Statistieken
38.5% of high-risk individuals were diagnosed at stage I, compared to 10.3% in the control group.
30.8% of high-risk individuals were diagnosed at stage II, compared to 25.1% in the control group.
The median tumor size at diagnosis was 2.5 cm in high-risk individuals, compared to 3.6 cm in the control group.
26.9% of high-risk individuals had distant metastases at diagnosis, compared to 53.8% in the control group.
The median overall survival was 61.7 months in high-risk individuals, compared to 8 months in the control group.
The 5-year survival probability was 50% in the high-risk group, compared to 9% in the control group.
Citaten
"Surveillance of high-risk individuals led to detection of smaller pancreatic cancers, a greater number of patients with stage I disease, and a much higher likelihood of long-term survival than unscreened patients in the general population."
"These findings suggest that selective surveillance of individuals at high risk for pancreatic cancer may improve clinical outcomes."