Grunnleggende konsepter
Lymphoid structures in the meninges play a crucial role in supporting humoral immunity and rapid immune responses to pathogens.
Sammendrag
The content discusses the discovery of lymphoid structures in the dura mater that support humoral immunity and immune responses to pathogens. These structures, termed dural-associated lymphoid tissues (DALT), are found around vasculature in the meninges and contain germinal center B cells. Key highlights include:
- Identification of organized lymphoid structures protecting fenestrated vasculature in the dura mater.
- Description of the rostral-rhinal venolymphatic hub as a key structure interfacing with skull bone marrow and venous plexus.
- Presence of immune aggregates in DALT during homeostasis, expanding with age or antigen challenge.
- Role of DALT in generating somatically mutated, antibody-producing cells in response to nasal pathogen challenge.
- Impact of inhibiting lymphocyte entry into the rostral-rhinal hub on germinal center B cell generation and plasma cell production.
- Demonstration of how these lymphoid structures sample antigens and support rapid humoral immune responses to local pathogens.
Statistikk
The outer layer of the meninges, the dura mater, contains both innate and adaptive immune cells (source: Content).
DALT contain germinal centre B cells that support antibody production (source: Content).
Sitater
"Immune aggregates were present in DALT during homeostasis and expanded with age or after challenge with systemic or nasal antigens." - Content
"These data demonstrate a lymphoid structure around vasculature in the dura mater that can sample antigens and rapidly support humoral immune responses after local pathogen challenge." - Content