Harnessing Artificial Intelligence to Build Comprehensive Virtual Cell Models: Priorities, Opportunities, and Challenges
Artificial intelligence (AI) and the exponential growth in biological data present an unprecedented opportunity to construct comprehensive virtual cell models that can simulate cellular behavior, predict responses to perturbations, and uncover underlying mechanisms.
A Generalist Model for Robust Axon and Myelin Segmentation Across Diverse Histology Imaging Modalities
A generalist deep learning model for axon and myelin segmentation that outperforms dedicated single-domain models and generalizes better to out-of-distribution data by aggregating diverse histology imaging datasets.
Molecular Mesh Buildup Around Hunger Neurons Drives Obesity in Mice
Buildup of a molecular meshwork around neurons in the arcuate nucleus of the hypothalamus blocks insulin signaling, leading to increased food intake, fat accumulation, and metabolic problems in obese mice.
腸道微生物透過剝奪營養來抑制有害細菌的入侵
腸道定植抵抗力的喪失會使潛在有害細菌大量入侵腸道,重建定植抵抗力是一個重要的臨床目標。腸道定常菌可以通過耗竭營養來抑制肺炎克雷伯氏菌等有害細菌的入侵。
장내 미생물이 영양분 고갈로 유해 박테리아를 막아내는 방식
장내 상주 박테리아가 영양분 고갈을 통해 Klebsiella pneumoniae와 같은 유해 박테리아의 장내 정착을 억제한다.
腸内細菌が有害細菌の侵入を阻止する仕組み - 栄養分の奪い合い
腸内細菌は、栄養分の奪い合いによって、有害細菌の腸内への侵入を阻止する。
How Gut Microbes Prevent Harmful Bacteria Invasion by Depriving Them of Nutrients
Gut commensal bacteria suppress colonization by harmful pathogens like Klebsiella pneumoniae through nutrient depletion.
肥胖和代謝性疾病的根源:視丘神經元外基質的病理性改變
視丘神經元外基質的病理性重塑是導致代謝性疾病的根本機制。
대사 질환을 유발하는 시상하부 세포외기질의 역할
대사 질환에서 시상하부 아급핵 신경세포를 둘러싼 특수 세포외기질인 페리뉴런 네트워크의 변화가 인슐린 저항성과 대사 기능 장애를 유발한다.
Extracellular Matrix Remodeling in the Hypothalamus Contributes to Metabolic Disorders
Remodeling of the specialized extracellular matrix, termed perineuronal net, surrounding neurons in the arcuate nucleus of the hypothalamus drives insulin resistance and metabolic dysfunction in obesity and type 2 diabetes.
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