Grunnleggende konsepter
The parasitic nematode Heligmosomoides polygyrus bakeri secretes a family of proteins (HpARI) that modulate the host immune response by binding to the cytokine IL-33, with HpARI1 and HpARI2 suppressing and HpARI3 enhancing IL-33 activity; the differential activity is determined by the ability of HpARI1 and HpARI2, but not HpARI3, to bind to heparan sulphate, which increases their half-life and retains them at the site of infection.
Colomb, F., Ogunkanbi, A., Jamwal, A., Dong, B., Maizels, R. M., Finney, C. A. M., Wasmuth, J. D., Higgins, M. K., & McSorley, H. J. (2024). IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses. Infection and Immunity, 92(3), e0039523. https://doi.org/10.1128/iai.00395-23
This study investigates the molecular mechanisms underlying the divergent effects of the HpARI protein family, secreted by the parasitic nematode Heligmosomoides polygyrus bakeri (Hpb), on the host immune response to the cytokine IL-33.