Grunnleggende konsepter
Genes ADRA2A and IRX1 linked to Raynaud disease.
Sammendrag
Researchers identified genes ADRA2A and IRX1 linked to Raynaud disease, impacting blood vessel constriction and dilation. The study, published in Nature Communications, analyzed data from the UK Biobank and Queen Mary University of London Genes & Health Study. Primary Raynaud is the focus, with potential implications for secondary Raynaud. New therapeutic avenues may arise from these genetic findings.
Statistikk
Raynaud affects 2%-5% of the general population.
5100 individuals with Raynaud identified in the UK Biobank.
ADRA2A encodes for alpha-2A adrenergic receptor.
IRX1 gene associated with regulating blood vessel dilation.
Sitater
"Our finding of alpha-2A receptors is quite interesting because the focus has always been on alpha-2C receptors." - Maik Pietzner
"The study is the largest of this kind that's been done." - Laura Hummers