The content discusses a breakthrough in HIV cure research, where a patient has achieved long-term HIV remission after receiving a stem cell transplant from a donor with a single CCR5 delta 32 mutation. This is significant because previous HIV cure cases have involved donors with two copies of the CCR5 delta 32 mutation, which are harder to find.
The anonymous patient, referred to as the "next Berlin patient," is the first to achieve long-term HIV remission (approaching 6 years) after receiving a CCR5 wild-type, delta 32 transplant, known as a heterozygous transplant, for acute myeloid leukemia. Other cured patients have received stem cell transplants from donors with two copies of the CCR5 delta 32 mutation, known as homozygous.
Researchers are hopeful that this case will expand the pool of potential donors and the availability of allogeneic stem cell transplantation for HIV cure efforts. The key mechanism in a cure is the depletion of the HIV reservoir, and this case suggests that HIV remission and potential cure can be achieved independently of the CCR5 status.
The content also discusses the case of the "Geneva patient," who received a stem cell transplant from a wild-type CCR5 donor and experienced long-term HIV remission. Researchers emphasize the need for further research to understand the underlying mechanisms and translate the findings of these cases for HIV cure research globally.
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by Richard Mark... klokken www.medscape.com 07-29-2024
https://www.medscape.com/viewarticle/latest-hiv-cure-case-comes-twist-2024a1000dvrDypere Spørsmål