Grunnleggende konsepter
High-dose vitamin E can induce coagulopathy even at marginally increased levels.
Sammendrag
Abstract and Introduction
High-dose vitamin E can inhibit vitamin K-derived coagulation factor synthesis.
Case study of a 31-year-old man with vitamin E-induced coagulopathy.
Diagnosis involved deficiency of multiple coagulation factors due to acquired vitamin K deficiency.
Treatment included pantoprazole, vitamin K supplementation, and fresh frozen plasma transfusions.
Patient recovered with complete resolution of symptoms.
Conclusions
Vitamin E can inhibit vitamin K-dependent factors causing coagulopathy.
Risk increases in patients taking other drugs that raise bleeding risk.
Introduction
Vitamin E toxicity is rare but can occur in cases of altered absorption or excretion.
High-dose vitamin E inhibits vitamin K-related enzyme activation for coagulation factor synthesis.
Deficiency of factors II, VII, IX, and X can lead to bleeding.
Vitamin E excess inhibits factor IX activation and platelet aggregation.
Vitamin E toxicity can present with coagulopathies and general symptoms.
Uncertainty exists regarding the minimum dose and duration of vitamin E intake to affect coagulation pathways.
Statistikk
Serum fibrinogen was slightly raised.
Serum alpha-tocopherol was slightly raised.
Prothrombin induced by vitamin K absence-II level was increased.
Sitater
"Vitamin E-related inhibition of vitamin K-dependent factors with coagulopathy may occur even at marginally increased levels of serum vitamin E."
"Vitamin E toxicity may be overlooked as the cause of coagulopathy if serum levels of vitamin E are only marginally increased."