Grunnleggende konsepter
A novel injectable semaglutide-loaded hydrogel formulation demonstrates extended drug release over one month and good tolerability in preclinical studies, potentially improving patient adherence and treatment outcomes for type 2 diabetes and obesity.
Sammendrag
The article discusses the development and evaluation of two experimental versions of a monthly injectable semaglutide-loaded hydrogel for the treatment of type 2 diabetes and obesity.
Key highlights:
- Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist approved for treating obesity with or without type 2 diabetes, but current once-weekly subcutaneous injections or daily oral pills may have suboptimal adherence.
- The researchers developed two hydrogel formulations that form either a gel disk or microgel suspension after injection, enabling gradual and prolonged drug release over one month.
- In preclinical studies with rats, the hydrogel formulations demonstrated a minimal initial burst release followed by consistent semaglutide release over the course of one month, with good tolerability and no adverse reactions.
- The hydrogel could be easily injected using a 25G needle and was well-tolerated, with the potential to improve patient adherence and treatment outcomes compared to current semaglutide administration methods.
Statistikk
The formulations were injected subcutaneously in six wild-type Wistar Han male rats of normal weight (250-300 g) to characterize semaglutide pharmacokinetics and hydrogel biocompatibility.
A single injection of the hydrogel-based formulations in rats demonstrated a minimal initial early release, followed by a consistent release over the course of 1 month.
Sitater
"A small dollop of gel, known as a 'depot,' of the semaglutide-laden hydrogel is injected under the skin. Our pre-clinical results demonstrate that the regular, slow release of semaglutide over one month after administering a single dose, with limited early release, is achievable."
Claire Mégret, PhD, lead author of the poster presentation