
深海化学合成共生体の宿主-共生体相互作用と環境適応メカニズムを明らかにした。


coremsg

Bathymodioline mussels dominate deep-sea methane seep and hydrothermal vent habitats and obtain nutrients and energy primarily through chemosynthetic endosymbiotic bacteria in the bacteriocytes of their gill. However, the molecular mechanisms that orchestrate mussel host-symbiont interactions remain unclear. Here, we constructed a comprehensive cell atlas of the gill in the mussel Gigantidas platifrons from the South China Sea methane seeps (1100m depth) using single-nucleus RNA sequencing (snRNA-seq) and whole-mount in situ hybridisation. We identified 13 types of cells, including three previously unknown ones, and uncovered unknown tissue heterogeneity. Every cell type has a designated function in supporting the gill’s structure and function, creating an optimal environment for chemosynthesis, and effectively acquiring nutrients from the endosymbiotic bacteria. Analysis of snRNA-seq of in situ transplanted mussels clearly showed the shifts in cell state in response to environmental oscillations. Our findings provide insight into principles of host-symbiont interaction and the bivalves’ environmental adaption mechanisms.

### Competing Interest Statement

The authors have declared no competing interest.

Deciphering deep-sea chemosynthetic symbiosis by single-nucleus RNA-sequencing

深海化学合成共生体の単一核rna配列解析による解明


深海化学合成共生体の単一核RNA配列解析による解明
