Structural and Energetic Insights into Ligand-Induced Conformational Changes in a Cyclic Nucleotide-Gated Ion Channel using Time-Resolved Transition Metal Ion FRET
Binding of the full agonist cAMP induces large structural changes and favorable energetics in the C-terminal region of the cyclic nucleotide-gated ion channel SthK, while the partial agonist cGMP promotes a smaller fraction of the active conformation.