
STIL 과발현은 중심체 증폭과 염색체 부정합을 유발하여 세포 증식 억제, 세포 노화 및 세포 사멸을 유발하며, 이로 인해 마우스의 수명이 단축되고 자발적 종양 형성이 감소한다.


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Centrosomes are the major microtubule organizing centers of animal cells. Supernumerary centrosomes are a common feature of human tumors and associated with karyotype abnormalities and aggressive disease, but whether they are cause or consequence of cancer remains controversial. Here, we analyzed the consequences of centrosome amplification by generating transgenic mice in which centrosome numbers can be increased by overexpression of the structural centrosome protein STIL. We show that STIL overexpression induces centrosome amplification and aneuploidy, leading to senescence, apoptosis, and impaired proliferation in mouse embryonic fibroblasts, and microcephaly with increased perinatal lethality and shortened lifespan in mice. Importantly, both overall tumor formation in mice with constitutive, global STIL overexpression and chemical skin carcinogenesis in animals with inducible, skin-specific STIL overexpression were reduced, an effect that was not rescued by concomitant p53 inactivation. These results suggest that supernumerary centrosomes impair proliferation in vitro as well as in vivo , resulting in reduced lifespan and spontaneous as well as carcinogen-induced tumor formation.

### Competing Interest Statement

The authors have declared no competing interest.

STIL overexpression shortens lifespan and reduces tumor formation in mice

stil-과발현이-마우스의-수명을-단축시키고-종양-형성을-감소시킨다


STIL 과발현이 마우스의 수명을 단축시키고 종양 형성을 감소시킨다
