Deciphering the Substrate Specificities of the Major Staphylococcus aureus Peptidoglycan Hydrolases Lysostaphin and LytM
The major Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM display distinct substrate specificities, with lysostaphin preferring the D-Ala-Gly cross-link in mature peptidoglycan, while LytM can also cleave the D-alanyl-glycine bond in addition to glycyl-glycine bonds.