The article presents a revised and more comprehensive understanding of the embryonic origins of oligodendrocytes (OLs) in the forebrain, using advanced genetic fate mapping techniques. The key findings are:
Contrary to the canonical view, OLs derived from the lateral/caudal ganglionic eminences (LGE/CGE) make minimal contributions to the neocortex and corpus callosum, but dominate the piriform cortex and anterior commissure.
OLs derived from the medial ganglionic eminence/preoptic area (MGE/POA) make a small but sustained contribution to the cortex, with a distribution pattern distinct from those of the dorsal pallium-derived OLs.
The study provides new tools and strategies for future investigations of OL lineage and development in the forebrain.
The authors challenge the prevailing understanding of OL origins and establish a more nuanced picture of their diverse embryonic sources and regional distributions within the forebrain.
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by Cai,Y., Zhao... o www.biorxiv.org 01-23-2024
https://www.biorxiv.org/content/10.1101/2024.01.23.576886v3Głębsze pytania