spostrzeżenie - Health - # TG Metabolism and Mortality Risk

Triglyceride Metabolism and Mortality Risk Study

Q: What implications do these findings have for current approaches to assessing cardiovascular risk?

The findings from the study suggest that focusing solely on triglyceride (TG) levels may not be sufficient in assessing cardiovascular risk. Instead, the study indicates that the vigor of TG metabolism, as indicated by concentrations of glycerol and β-hydroxybutyrate, may be more strongly associated with adverse outcomes such as all-cause mortality, cardiovascular mortality, and cancer mortality. This challenges the traditional approach of primarily considering plasma TG levels as a key risk factor. Therefore, current approaches to assessing cardiovascular risk may need to incorporate measures of TG metabolism to provide a more comprehensive evaluation of an individual's risk profile.

Q: How might the concept of triglyceride metabolism as a risk factor challenge existing treatment strategies?

The concept of triglyceride metabolism as a risk factor introduces a new dimension to the understanding of cardiovascular risk and may challenge existing treatment strategies that primarily target reducing plasma TG levels. If the vigor of TG metabolism, as indicated by glycerol and β-hydroxybutyrate levels, is indeed a more significant predictor of adverse outcomes, treatment strategies focused solely on lowering TG levels may not be as effective in mitigating risk. This new insight suggests that interventions aimed at modulating TG metabolism, rather than just reducing TG levels, may be more beneficial in improving cardiovascular outcomes. Therefore, existing treatment strategies may need to be reevaluated to incorporate this novel understanding of TG metabolism as a risk factor.

Q: How can the use of glycerol and β-hydroxybutyrate as biomarkers for mortality risk be further validated and implemented in clinical practice?

To further validate and implement the use of glycerol and β-hydroxybutyrate as biomarkers for mortality risk in clinical practice, additional research and validation studies are necessary. These studies should aim to confirm the findings of the current study in diverse populations and settings to establish the generalizability of these biomarkers. Furthermore, longitudinal studies could help elucidate the causal relationship between TG metabolism markers and mortality outcomes. In clinical practice, healthcare providers could consider incorporating measurements of glycerol and β-hydroxybutyrate levels alongside traditional risk factors to enhance risk assessment and inform treatment decisions. Additionally, prospective studies evaluating the impact of interventions targeting TG metabolism on clinical outcomes could provide valuable insights into the utility of these biomarkers in guiding therapeutic strategies. Collaborative efforts between researchers, clinicians, and policymakers will be essential in translating these research findings into actionable strategies for improving cardiovascular risk assessment and management.

Główne pojęcia

Active triglyceride metabolism may be a stronger predictor of mortality risk than plasma triglyceride levels.

Streszczenie

The study focused on the association between triglyceride metabolism and mortality risk, suggesting that the vigor of TG metabolism, rather than plasma levels, is linked to adverse outcomes. The analysis, based on 30,000 participants, found increased risks for all-cause mortality, cardiovascular mortality, and cancer mortality among those with robust TG metabolism. The study highlighted the significance of glycerol and β-hydroxybutyrate concentrations as markers of TG metabolic rate, independent of traditional risk factors like BMI and plasma TG levels. The findings challenge conventional beliefs about TG and mortality risk, emphasizing the need to consider metabolic rate in risk assessments.

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www.medscape.com

Statystyki

All-cause mortality jumped 31% for plasma levels of glycerol in the highest vs lowest quartiles.
CV mortality climbed 37% for glycerol and 18% for β-hydroxybutyrate.
Hazard Ratios for 10-year Mortality for TG Metabolite Levels in Highest vs Lowest Quartiles:

All-cause: Glycerol 1.31 (1.22 - 1.40), β-hydroxybutyrate 1.18 (1.11 - 1.26)
Cardiovascular: Glycerol 1.37 (1.18 - 1.59), β-hydroxybutyrate 1.18 (1.03 - 1.35)
Cancer: Glycerol 1.24 (1.11 - 1.39), β-hydroxybutyrate 1.16 (1.05 - 1.29)
Other causes: Glycerol 1.45 (1.28 - 1.66), β-hydroxybutyrate 1.23 (1.09 - 1.39)

Cytaty

"The findings implicate triglyceride metabolic rate as a risk factor for mortality not explained by high plasma triglycerides or high BMI."
"The results were really surprising and may make people think differently about TG and mortality risk."

Kluczowe wnioski z

Triglyceride Puzzle: Do TG Metabolites Better Predict Risk?

by Steve Stiles o www.medscape.com 08-23-2023

https://www.medscape.com/viewarticle/995764

Triglyceride Puzzle: Do TG Metabolites Better Predict Risk?

Głębsze pytania

What implications do these findings have for current approaches to assessing cardiovascular risk?

The findings from the study suggest that focusing solely on triglyceride (TG) levels may not be sufficient in assessing cardiovascular risk. Instead, the study indicates that the vigor of TG metabolism, as indicated by concentrations of glycerol and β-hydroxybutyrate, may be more strongly associated with adverse outcomes such as all-cause mortality, cardiovascular mortality, and cancer mortality. This challenges the traditional approach of primarily considering plasma TG levels as a key risk factor. Therefore, current approaches to assessing cardiovascular risk may need to incorporate measures of TG metabolism to provide a more comprehensive evaluation of an individual's risk profile.

How might the concept of triglyceride metabolism as a risk factor challenge existing treatment strategies?

The concept of triglyceride metabolism as a risk factor introduces a new dimension to the understanding of cardiovascular risk and may challenge existing treatment strategies that primarily target reducing plasma TG levels. If the vigor of TG metabolism, as indicated by glycerol and β-hydroxybutyrate levels, is indeed a more significant predictor of adverse outcomes, treatment strategies focused solely on lowering TG levels may not be as effective in mitigating risk. This new insight suggests that interventions aimed at modulating TG metabolism, rather than just reducing TG levels, may be more beneficial in improving cardiovascular outcomes. Therefore, existing treatment strategies may need to be reevaluated to incorporate this novel understanding of TG metabolism as a risk factor.

How can the use of glycerol and β-hydroxybutyrate as biomarkers for mortality risk be further validated and implemented in clinical practice?

To further validate and implement the use of glycerol and β-hydroxybutyrate as biomarkers for mortality risk in clinical practice, additional research and validation studies are necessary. These studies should aim to confirm the findings of the current study in diverse populations and settings to establish the generalizability of these biomarkers. Furthermore, longitudinal studies could help elucidate the causal relationship between TG metabolism markers and mortality outcomes.
In clinical practice, healthcare providers could consider incorporating measurements of glycerol and β-hydroxybutyrate levels alongside traditional risk factors to enhance risk assessment and inform treatment decisions. Additionally, prospective studies evaluating the impact of interventions targeting TG metabolism on clinical outcomes could provide valuable insights into the utility of these biomarkers in guiding therapeutic strategies. Collaborative efforts between researchers, clinicians, and policymakers will be essential in translating these research findings into actionable strategies for improving cardiovascular risk assessment and management.