Conceitos essenciais
Genetic evidence significantly increases the probability of success for drug mechanisms, with a 2.6-fold higher success rate compared to those without genetic support, providing valuable insights to aid the discovery of more effective drug targets.
Resumo
This study examines the impact of genetic evidence on the success rate of drug development, leveraging the growth in genetic data over the past decade. The key findings are:
- The probability of success for drug mechanisms with genetic support is 2.6 times greater than those without genetic evidence.
- The relative success rate varies across different therapy areas and development phases.
- The success rate improves with increasing confidence in the causal gene, but is largely unaffected by the genetic effect size, minor allele frequency, or year of discovery.
- These results indicate that there is significant untapped potential in leveraging genetic insights to aid the discovery of more effective drug targets and improve the overall success of the drug development process.
The study highlights the importance of incorporating genetic evidence into the drug discovery and development pipeline to enhance the chances of clinical success. As the availability of genetic data continues to grow, the findings suggest that we are far from reaching the peak of genetic insights that can be utilized to drive more effective drug discovery.
Estatísticas
Only about 10% of clinical programs eventually receive approval.
The probability of success for drug mechanisms with genetic support is 2.6 times greater than those without genetic evidence.
Citações
"We previously estimated that human genetic evidence doubles the success rate from clinical development to approval."
"These results indicate we are far from reaching peak genetic insights to aid the discovery of targets for more effective drugs."