The content discusses a new discovery in diabetic keratopathy treatment, focusing on differences in the eyes of individuals with and without diabetes. It highlights the impairments in epithelial wound healing, barrier function, and tear production associated with diabetic keratopathy. The research isolates limbal epithelial stem cells and identifies significant DNA methylation differences, leading to the repression of the WNT5A gene. Treatment with methylation inhibitors and nanoconjugates targeting WNT5A has shown improvements in corneal wound healing and stem cell expression. The study emphasizes the potential of Wnt-5a as a stimulator for corneal epithelial wound healing in diabetic individuals, with implications for other diabetes-related wound healing problems.
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by Miriam E. Tu... às www.medscape.com 07-28-2023
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