The study explores how prediction error influences memory organization during fear extinction in rats. Gradual extinction protocols with small prediction errors were found to be more effective than standard extinction protocols with large prediction errors. The results support latent state models and suggest that context changes can influence the effectiveness of gradual extinction.
The experiments involved conditioning rats to fear a stimulus paired with shock, followed by gradual or standard extinction protocols. Gradual extinction led to less spontaneous recovery and reinstatement of fear responses compared to standard extinction. A shift in physical or temporal context reversed the advantage of gradual extinction over standard extinction.
Overall, the findings highlight the importance of prediction error in encoding new information into memory states during fear extinction processes.
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by Kennedy,N. G... às www.biorxiv.org 01-16-2024
https://www.biorxiv.org/content/10.1101/2024.01.16.575867v1Perguntas Mais Profundas