Conceitos essenciais
Aβ3pE-42是阿茲海默症患者大腦中一種代謝穩定的澱粉樣蛋白β胜肽,其生成和累積與疾病進程密切相關,針對Aβ3pE-42的治療策略可能在疾病早期干預中更為有效。
Estatísticas
Aβ3pE-42佔AD患者大腦中總Aβ的50%或更多。
Aβ1-42在30分鐘內幾乎完全降解,而Aβ3pE-42在給藥到海馬體60分鐘後仍未被分解代謝。
App基因敲入小鼠大腦中Aβ3pE-42的相對含量僅佔總Aβ42的不到1%。
Citações
"Aβ3pE-42 is thus likely to be a probabilistic by-product of Aβ1-42 metabolism that selectively accumulates over a long-time range of brain aging. It is likely produced in the solid state or at the solid-liquid interface."
"Our findings suggest that anti-Aβ therapies will probably be most effective if given before Aβ3pE-42 deposition takes place."