Cbfβ Regulates Key Signaling Pathways to Maintain Articular Cartilage Homeostasis and Protect Against Osteoarthritis Development
Cbfβ is a critical transcriptional regulator that maintains articular cartilage homeostasis by modulating Wnt/β-catenin, Hippo/Yap, and TGF-β signaling pathways. Deficiency of Cbfβ leads to spontaneous osteoarthritis development, while overexpression of Cbfβ protects against surgically-induced osteoarthritis.