
XAP5와 XAP5L은 척수 섬모 발달을 조절하는 대립 전사 인자이다. XAP5는 척수 섬모 관련 유전자 발현을 활성화하고, XAP5L은 이를 억제함으로써 척수 섬모 발달을 시간과 공간적으로 조절한다.


coremsg

Existence of cilia in the last eukaryotic common ancestor (LECA) raises a fundamental question in biology: how the transcriptional regulation of ciliogenesis has evolved? One conceptual answer to this question is by an ancient transcription factor regulating ciliary gene expression in both unicellular and multicellular organisms, but examples of such transcription factors in eukaryotes are lacking. Previously, we showed that an ancient transcription factor XAP5 is required for flagellar assembly in Chlamydomonas . Here, we show that XAP5 and XAP5L are two conserved pairs of antagonistic transcription regulators that control ciliary transcriptional programs during spermatogenesis. Male mice lacking either XAP5 or XAP5L display infertility, as a result of meiotic prophase arrest and sperm flagella malformation, respectively. Mechanistically, XAP5 positively regulates the ciliary gene expression by activating the key regulators including FOXJ1 and RFX families during the early stage of spermatogenesis. In contrast, XAP5L negatively regulates the expression of ciliary genes via repressing these ciliary transcription factors during the spermiogenesis stage. Our results provide new insights into the mechanisms by which temporal and spatial transcription regulators are coordinated to control ciliary transcriptional programs during spermatogenesis.

### Competing Interest Statement

The authors have declared no competing interest.

Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors

척수-섬모-전사-프로그램의-대립-전사-인자에-의한-조절


척수 섬모 전사 프로그램의 대립 전사 인자에 의한 조절
