
The author argues that NSF triggers a change from fermentation to respiration-like gene expression, impacting adaptive growth in S. pombe by interacting with mitochondrial sulfide:quinone oxidoreductase Hmt2.


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Microbes have evolved intricate communication systems that enable individual cells of a population to send and receive signals in response to changes in their immediate environment. In the fission yeast Schizosaccharomyces pombe , the oxylipin Nitrogen Signaling Factor (NSF) is part of such communication system, which functions to regulate the usage of different nitrogen sources. Yet, the pathways and mechanisms by which NSF acts are poorly understood. Here, we show that NSF physically interacts with the mitochondrial sulfide:quinone oxidoreductase Hmt2 and that it prompts a change from a fermentation- to a respiration-like gene expression program independently of the carbon source. Our results suggest that NSF activity is not restricted to nitrogen metabolism alone and that it could function as a rheostat to prepare a population of S. pombe cells for an imminent shortage of their preferred nutrients.

Nitrogen signaling factor triggers a respiration-like gene expression program

Nitrogen-Signaling-Factor-Impact-on-Gene-Expression-in-Yeast


Nitrogen Signaling Factor Impact on Gene Expression in Yeast
