
Weight loss does not erase the obesogenic memory in adipose tissue; epigenetic changes persist and contribute to accelerated weight regain and metabolic dysfunction.


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Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to the problematic ‘yo-yo’ effect often seen with dieting.

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature

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Adipose Tissue Retains an Epigenetic Memory of Obesity Even After Weight Loss, Contributing to Weight Regain
