
Propofol, a general anesthetic, inhibits HCN1 channels by binding to a specific site between the S5 and S6 transmembrane helices, and can restore voltage-dependent closing in two HCN1 epilepsy-associated polymorphisms that destabilize the channel's closed state.


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Propofol repairs malfunctioning mutant HCN1 channels associated with epilepsy, and its unusual mechanism of action on these ion channels can potentially be exploited to design precision drugs targeting HCN channelopathies.

Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants - Nature

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Propofol Restores Voltage-Dependent Gating in HCN1 Channel Epilepsy Mutations
