Upregulation of Ubiquitin Ligase TRIM21 Promotes Nuclear Translocation of PKM2 and Astrocyte Activation in Experimental Autoimmune Encephalomyelitis
Upregulation of the ubiquitin ligase TRIM21 promotes the nuclear translocation of PKM2, which in turn activates the STAT3 and NF-κB pathways and enhances glycolysis and proliferation in astrocytes, contributing to the development of experimental autoimmune encephalomyelitis.