
Mechanical activation induces a lipid-lined pore formation in OSCA/TMEM63 mechanosensitive ion channels, which play critical roles in plant and mammalian mechanotransduction.


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The molecular basis of OSCA/TMEM63 channel mechanosensitivity was investigated by determining 44 cryogenic electron microscopy structures of channels in different environments, expanding understanding of channel-mediated mechanotransduction and pore formation, with implications for two protein families.

Mechanical activation opens a lipid-lined pore in OSCA ion channels - Nature

cryo-em-structures-reveal-lipid-lined-pore-formation-in-mechanosensitive-osca-ion-channels


Cryo-EM Structures Reveal Lipid-Lined Pore Formation in Mechanosensitive OSCA Ion Channels
