
성전환 호르몬 치료는 성전환자 여성의 고환 내 소마 세포를 부분적으로 미성숙 상태로 되돌리고 섬유화 과정을 유발한다.


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Although the impact of gender-affirming hormone therapy (GAHT) on spermatogenesis in trans women has already been studied, data on its precise effects on the testicular environment is poor. Therefore, this study aimed to characterize, through histological and transcriptomic analysis, the spermatogonial stem cell niche of 106 trans women who underwent standardized GAHT, comprising estrogens and cyproterone acetate. A partial dedifferentiation of Sertoli cells was observed, marked by the co-expression of androgen receptor and anti-Müllerian hormone which mirrors the situation in peripubertal boys. The Leydig cells also exhibited a distribution analogous to peripubertal tissue, accompanied by a reduced insulin-like factor 3 expression. Although most peritubular myoid cells expressed alpha-smooth muscle actin 2, the expression pattern was disturbed. Besides this, fibrosis was particularly evident in the tubular wall and the lumen was collapsing in most participants. A spermatogenic arrest was also observed in all participants. The transcriptomic profile of transgender tissue confirmed a partial rejuvenation and, in addition, detected inflammation processes occurring in the samples. The present study shows that GAHT changes the spermatogonial stem cell niche by partially rejuvenating the somatic cells and inducing fibrotic processes. These findings are important to further understand how estrogens and testosterone suppression affect the testis environment, and in the case of orchidectomized testes as medical waste material, their potential use in research.

### Competing Interest Statement

The authors have declared no competing interest.

Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

성전환자-여성의-성전환-호르몬-치료-후-부분적인-정모세포-줄기세포-영역-재생


성전환자 여성의 성전환 호르몬 치료 후 부분적인 정모세포 줄기세포 영역 재생
