
単一の抑制性 Ly49 受容体の発現で NK 細胞の免疫機能が十分に発揮される


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Natural killer (NK) cells recognize target cells through germline-encoded activation and inhibitory receptors enabling effective immunity against viruses and cancer. The Ly49 receptor family in the mouse and killer immunoglobin-like receptor family in humans play a central role in NK cell immunity through recognition of MHC class I and related molecules. Functionally, these receptor families are involved in licensing and rejection of MHC-I-deficient cells through missing-self. The Ly49 family is highly polymorphic, making it challenging to detail the contributions of individual Ly49 receptors to NK cell function. Herein, we showed mice lacking expression of all Ly49s were unable to reject missing-self target cells in vivo , were defective in NK cell licensing, and displayed lower KLRG1 on the surface of NK cells. Expression of Ly49A alone on a H-2Dd background restored missing-self target cell rejection, NK cell licensing, and NK cell KLRG1 expression. Thus, a single inhibitory Ly49 receptor is sufficient to license NK cells and mediate missing-self in vivo .

### Competing Interest Statement

The authors have declared no competing interest.

Expression of a single inhibitory Ly49 receptor is sufficient to license NK cells for effector functions

単一の抑制性-ly49-受容体の発現で-nk-細胞の効果機能を引き起こすことが十分である


単一の抑制性 Ly49 受容体の発現で NK 細胞の効果機能を引き起こすことが十分である
