2-Oxoglutarate Triggers Assembly of Active Dodecameric Methanosarcina mazei Glutamine Synthetase
2-Oxoglutarate (2-OG) is the central activator of Methanosarcina mazei glutamine synthetase (GlnA1), triggering its assembly into an active dodecameric complex and inducing a conformational switch towards a catalytically competent state.