The suppressive function of regulatory T cells (Treg) relies on antigen receptor signaling triggered by various antigens. A mouse model with a fixed TCRβ chain was used to analyze conventional and regulatory effector TCRα repertoires in response to different lung and skin challenges. The study revealed challenge-specific clonal expansions within tissues, draining lymph nodes, and across animals. Some clusters were shared across cancer challenges, indicating a response to common tumor-associated antigens. The distinct origin of eCD4 and eTreg subsets was observed for most challenges, but overlap was noted at certain tumor sites. Additionally, the study demonstrated that resident eTreg populations have distinct antigenic specificities based on their tissue location.
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biorxiv.org
ข้อมูลเชิงลึกที่สำคัญจาก
by Nakonechnaya... ที่ www.biorxiv.org 06-15-2023
https://www.biorxiv.org/content/10.1101/2023.06.15.544726v4สอบถามเพิ่มเติม