Induction of Regenerative Cardiac Cells from Cardiomyocytes Using a Two-Drug Combination: In Vitro and In Vivo Evidence
A novel two-drug combination, CHIR99021 and A-485 (2C), effectively reprograms human cardiomyocytes into regenerative cardiac cells (RCCs) in vitro and improves cardiac function in mice following myocardial infarction.