
만성적인 열 노출은 시상후부 시상밑핵(pPVT) 뉴런의 활동을 변화시켜 부정적인 감정과 과각성 상태를 유발한다.


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Mental and behavioral disorders are associated with extended period of hot weather as found in heatwaves, but the underlying neural circuit mechanism is poorly known. The posterior paraventricular thalamus (pPVT) is a hub for emotional processing and receives inputs from the hypothalamic preoptic area (POA), the well-recognized thermoregulation center. The present study was designed to explore whether chronic heat exposure leads to aberrant activities in POA recipient pPVT neurons and subsequent changes in emotional states. By devising an air heating paradigm mimicking the condition of heatwaves and utilizing emotion-related behavioral tests, viral track tracing, in vivo calcium recordings, optogenetic manipulations and electrophysiological recordings, we found that chronic heat exposure for 3 weeks led to negative emotional and hyperarousal states in mice. The pPVT neurons receive monosynaptic excitatory and inhibitory innervations from the POA. These neurons exhibited a persistent increase in neural activity following chronic heat exposure, which was essential for chronic heat-induced emotional changes. Notably, these neurons were also prone to display stronger neuronal activities associated with anxiety responses to stressful situations. Furthermore, we observed saturated neuroplasticity in the POA-pPVT excitatory pathway after chronic heat exposure that occluded further potentiation. Taken together, long-term aberration in the POA to pPVT pathway offers a neurobiological mechanism of emotional and behavioral changes seen in extended period of hot weather like heatwaves.

### Competing Interest Statement

The authors have declared no competing interest.

Repeated activation of preoptic area-recipient neurons in posterior paraventricular nucleus mediates chronic heat-induced negative emotional and hyperarousal states

시상후부-시상밑핵에서-시상전핵-수용-뉴런의-반복적-활성화는-만성-열-노출로-인한-부정적-감정-및-과각성-상태를-매개한다


시상후부 시상밑핵에서 시상전핵 수용 뉴런의 반복적 활성화는 만성 열 노출로 인한 부정적 감정 및 과각성 상태를 매개한다
