Precise Regulation of Transposon Methylation in Germline Development Requires Two-Factor Authentication in the piRNA Pathway
The piRNA pathway precisely regulates DNA methylation of young, active transposons during germline development in male mice through a two-factor authentication process involving the recruitment of SPIN1-SPOCD1 complex to young LINE1 promoters, followed by engagement of MIWI2 with the nascent transcript.