Structural Pharmacology and Therapeutic Potential of 5-Methoxytryptamines: Insights into 5-HT1A Receptor Signaling and Psychedelic Drug Development

Psychedelic substances like 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) show therapeutic potential, but their mechanisms of action through the 5-HT1A receptor are not well understood. This study provides structural, pharmacological, and behavioral insights that can guide the development of 5-HT1A-targeted psychedelic therapeutics for neuropsychiatric disorders.