Temel Kavramlar
H. pylori infection may increase Alzheimer's risk.
Özet
The study suggests that adults with recent Helicobacter pylori infection have an 11% increased risk of Alzheimer's disease (AD) compared to those without exposure. The research, published in Alzheimer's & Dementia, analyzed a cohort of 4,262,092 patients aged 50 or older without dementia. The study cohort was taken from the UK Clinical Practice Research Datalink (CPRD) GOLD, covering over 11 million patients. AD was defined based on specific criteria, and patients with clinically apparent H. pylori infection (CAHPI) were studied. The mean age of participants was 60.4 years, with 52.1% being women. Exposure to CAHPI was linked to a moderate but statistically significant increase in AD risk, peaking 7.3-10.8 years after infection onset.
İstatistikler
In a cohort of 4,262,092 patients aged 50 or older without dementia, CAHPI was associated with an 11% increased risk for AD.
Exposure to CAHPI was linked to a moderate but statistically significant increase in the risk for AD (odds ratio [OR], 1.11).
The increase in risk peaked at 7.3-10.8 years after CAHPI onset (OR, 1.24).
Alıntılar
"Our result confirms the assumption that H pylori infection could be a modifiable risk factor for AD." - Paul Brassard, MD