Temel Kavramlar
Mitochondrial complex I activity in microglia drives neuroinflammation, highlighting its role as a potential therapeutic target for chronic inflammatory disorders of the central nervous system.
Özet
Sustained activation of myeloid cells is a common feature in chronic neurological diseases like multiple sclerosis. Metabolic and mitochondrial features play a crucial role in guiding the activation of myeloid cells. A molecular signature identified through a multiomics approach reveals that mitochondrial complex I activity in microglia drives reverse electron transport and reactive oxygen species production, perpetuating inflammation in the central nervous system. Blocking complex I in pro-inflammatory microglia shows promise in protecting against neurotoxic damage and improving functional outcomes in animal disease models, suggesting it as a potential therapeutic target for neuroprotection in chronic inflammatory disorders.
İstatistikler
Mitochondrial complex I activity drives reverse electron transport and reactive oxygen species production.
Blocking complex I protects against neurotoxic damage and improves functional outcomes.