
Cryo-EM structures of the noradrenaline transporter reveal a dimeric interface mediated by cholesterol and lipids, the binding mode of the substrate noradrenaline, and the recognition of various antidepressants, providing a structural basis for understanding transporter regulation and inhibition.


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Cryo-electron microscopy structures of the noradrenaline transporter in the apo state, bound to noradrenaline and bound to various antidepressants shed light on the substrate transport, molecular recognition and dimeric architecture of this protein.

Dimerization and antidepressant recognition at noradrenaline transporter - Nature

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Structural Insights into Noradrenaline Transporter Dimerization and Antidepressant Binding
