The study investigated how task rules modulate the sensorimotor transformation in a cross-modal sensory selection task. Key findings:
Single-neuron and population activity in the somatosensory (S1, S2) and motor (MM, ALM) cortical areas reflected the current task rule, both before and in response to the tactile stimulus.
Neural subspaces containing the trial activity differed between the two rules across the cortical areas, and the pre-stimulus subspace overlap predicted the subsequent divergence of neural trajectories.
Pre-stimulus population states in the motor cortical areas (MM, ALM) shifted in a manner that tracked the rule switch, while the sensory cortical areas (S1, S2) showed limited rule-dependent changes.
Optogenetic disruption of pre-stimulus states within the motor cortical areas impaired rule-dependent tactile detection, but not simple tactile detection.
These results indicate that flexible selection of appropriate actions in response to sensory inputs is achieved through rule-dependent configuration of preparatory states in the motor cortex.
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by Chang,Y.-T.,... 於 www.biorxiv.org 08-22-2023
https://www.biorxiv.org/content/10.1101/2023.08.21.554194v2深入探究