Obesity research has long been rooted in the belief of an energy imbalance between calories consumed and expended. However, the author challenges this paradigm, asserting that obesity is not solely about overeating but rather a hormonal or constitutional disorder affecting fat storage. The historical evolution of obesity science reveals a persistent focus on energy balance at the expense of exploring fat metabolism. The article highlights key figures like Gustav von Bergmann and Julius Bauer who proposed early hypotheses on fat accumulation, contrasting with the dominant energy balance narrative. The discussion delves into animal models of obesity, such as ob/ob mice, challenging traditional assumptions about leptin's role in regulating appetite versus fat storage. Moreover, it critiques how energy balance thinking has led to characterizing obesity as a behavioral flaw rather than a physiological disorder. By examining historical perspectives and scientific evidence, the author advocates for reevaluating current approaches to combatting obesity by prioritizing understanding fat metabolism over simplistic notions of calorie intake.
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by Gary Taubes 於 www.statnews.com 09-13-2021
https://www.statnews.com/2021/09/13/how-a-fatally-tragically-flawed-paradigm-has-derailed-the-science-of-obesity/深入探究