
某些腸道微生物可以分解嘌呤，嘌呤是尿酸的前體，因此可能成為降低尿酸和治療痛風的新方法。


coremsg

Researchers have identified separate gut bacteria species that can metabolize purines and urate, suggesting that microbial pathways might be leveraged through probiotics to reduce hyperuricemia.

Gut Microbiome Has Potential to Counter Gout

腸道微生物群有望對抗痛風

title_rewrite


장내 미생물 중 일부는 요산의 생성을 억제하거나 분해하는 특성을 지니고 있어, 향후 통풍 치료제 개발에 활용될 가능성이 있다.


장내-미생물-통풍-치료의-새로운-가능성-제시


장내 미생물, 통풍 치료의 새로운 가능성 제시



腸内細菌叢、特に特定の種類の乳酸菌は、プリン体を分解し、尿酸値を下げることで、痛風の治療に役立つ可能性がある。


腸内細菌叢は痛風の治療に役立つ可能性がある


Research suggests that certain gut microbes, particularly some strains of Lactobacillus, can metabolize purines, potentially offering a new therapeutic avenue for lowering urate levels and managing gout.


gut-microbes-show-promise-as-potential-gout-treatment-by-metabolizing-purines


Gut Microbes Show Promise as Potential Gout Treatment by Metabolizing Purines



醫療機構應將醫師身心健康視為一項可衡量的品質指標，並收集相關數據以制定針對性的措施來解決職業倦怠問題。


Can wellness be measured like quality? Learn how organizations can use well-being metrics to support physicians and reduce burnout.

Physician Well-being Data: Insights to Improve Your Practice

如何利用醫師身心健康數據改善醫療實務


의사 웰빙을 측정 가능한 지표로 취급하고 데이터를 활용하여 번아웃이 심각한 부서를 파악하고 맞춤형 지원을 제공함으로써 의료 기관은 의사의 웰빙을 효과적으로 향상시킬 수 있습니다.


의사-웰빙-데이터-귀-병원-환경-개선을-위한-인사이트


의사 웰빙 데이터: 귀 병원 환경 개선을 위한 인사이트



医師のウェルビーイングを測定可能な指標として扱うことで、医療機関は燃え尽き症候群に優先順位をつけて対処できる。


医師のウェルビーイングデータ-医療現場を改善するための考察


医師のウェルビーイングデータ：医療現場を改善するための考察



Healthcare organizations should prioritize physician well-being by measuring burnout, comparing it to benchmarks, and implementing targeted interventions to address this critical issue.


measuring-and-addressing-physician-burnout-using-data-to-improve-well-being-and-practice


Measuring and Addressing Physician Burnout: Using Data to Improve Well-being and Practice



Redesigning workflows collaboratively, with input from all members of the clinical team, can reduce physician workload and burnout, leading to improved quality metrics and job satisfaction.


How can workflow changes reduce burnout in outpatient settings? Learn how a team-based approach improved efficiency, job satisfaction, and patient care.

Reduce Burnout With Collaborative Workflow Redesign

collaborative-workflow-redesign-a-solution-for-physician-burnout-in-outpatient-practices


Collaborative Workflow Redesign: A Solution for Physician Burnout in Outpatient Practices



TET2通過HNF4α-TET2-FBP1軸調控糖質新生，並可作為2型糖尿病治療的潛在靶點。


The control of gluconeogenesis is critical for glucose homeostasis and the pathology of type 2 diabetes (T2D). Here, we uncover a novel function of TET2 in the regulation of gluconeogenesis. In mice, both fasting and a high-fat diet (HFD) stimulate the expression of TET2, and TET2 knockout impairs glucose production. Mechanistically, FBP1, a rate-limiting enzyme in gluconeogenesis, is positively regulated by TET2 in liver cells. TET2 is recruited by HNF4α, contributing to the demethylation of FBP1 promoter and activating its expression in response to glucagon stimulation. Moreover, metformin treatment increases the phosphorylation of HNF4α on Ser313, which prevents its interaction with TET2, thereby decreasing the expression level of FBP1 and ameliorating the pathology of T2D. Collectively, we identify an HNF4α-TET2-FBP1 axis in the control of gluconeogenesis, which contributes to the therapeutic effect of metformin on T2D and provides a potential target for the clinical treatment of T2D.

### Competing Interest Statement

The authors have declared no competing interest.

TET2 contributes to gluconeogenesis and pathology of type 2 diabetes

tet2-促進糖質新生並參與-2-型糖尿病的病理過程


TET2 促進糖質新生並參與 2 型糖尿病的病理過程
