The content discusses a study that found evidence of Alzheimer's disease (AD) pathology being transmissible through bone marrow stem cell transplantation in preclinical models. The key findings are:
Transplantation of donor bone marrow stem cells carrying a mutant human amyloid precursor protein (APP) transgene into both APP-deficient and healthy wild-type mice resulted in the rapid development of AD pathological hallmarks.
These included compromised blood-brain barrier integrity, heightened cerebral vascular neoangiogenesis, elevated brain-associated beta-amyloid levels, and cognitive impairment.
The symptoms of cognitive decline presented more rapidly in the transplanted mice compared to typical AD transgenic mice.
The researchers suggest this reveals an "unexpected transmissible form of AD" and raises the possibility of "iatrogenic transmission in AD patients" through procedures involving stem cell transplantation.
However, several experts caution that the relevance to human transplantation is limited. They note that the familial form of AD is extremely rare, and there are already safeguards in place for stem cell transplantation. The experts do not believe the risks extend to other procedures like organ transplantation or blood transfusion.
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by Megan Brooks 於 www.medscape.com 03-28-2024
https://www.medscape.com/viewarticle/alzheimers-transmissible-stem-cell-transplantation-2024a10005x6深入探究