核心概念
Telomere length affects IL1 signaling, modulating immune response in TNBC.
摘要
Telomeres play a crucial role in cancer progression, impacting immune signaling and tumor microenvironment. Telomere length influences TRF2 binding at the IL1R1 promoter, affecting NF-kappaB activation and cytokine expression. Telomere-sensitive IL1 signaling correlates with TAM infiltration in TNBC, highlighting the role of telomeres in modulating tumor immunity.
統計資料
Telomerase activity negatively correlated with telomere length in TNBC.
TERC was significantly enhanced in TNBC-LT samples.
70% of TNBC samples showed lower telomere length in tumors compared to adjacent normal tissue.
EpCAM+ve cells exhibited significant TL heterogeneity between TNBC-ST and LT samples.
IL1R1, IL1B, TNF, and IL3 were lower in long telomere TNBC samples.
引述
"Enhanced TRF2 binding at the IL1R1 promoter directly recruits p300 for H3K27 acetylation."
"TRF2-K293R mutation compromised activation of IL1R1 due to reduced p300 recruitment."
"IL1 signaling through NF-kappaB activation is specifically regulated by TRF2."