
ElectroPhysiomeGANは、記録された膜電位応答と定常状態電流プロファイルから、Hodgkin-Huxleyタイプのニューロンモデルのパラメータを生成することができる。


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Recent advances in connectomics, biophysics, and neuronal electrophysiology warrant modeling of neurons with further details in both network interaction and cellular dynamics. Such models may be referred to as ElectroPhysiome, as they incorporate the connectome and individual neuron electrophysiology to simulate neuronal activities. The nervous system of C. elegans is considered a viable framework for such ElectroPhysiome studies due to advances in connectomics of its somatic nervous system and electrophysiological recordings of neuron responses. In order to achieve a simulated ElectroPhysiome, the set of parameters involved in modeling individual neurons need to be estimated from electrophysiological recordings. Here, we address this challenge by developing a novel deep generative method called ElectroPhysiomeGAN (EP-GAN), which once trained, can instantly generate parameters associated with the Hodgkin-Huxley neuron model (HH-model) for neurons with graded potential response. The method combines Generative Adversarial Network (GAN) architecture with Recurrent Neural Network (RNN) Encoder and can generate an extensive number of parameters (>170) given the neuron’s membrane potential responses and steady-state current profiles. We validate our method by estimating HH-model parameters for 200 synthetic neurons with graded membrane potential followed by 9 experimentally recorded neurons (where 6 of them newly recorded) in the nervous system of C. elegans . Compared to other methods, EP-GAN is advantageous in both accuracy of generated parameters and inference speed. In addition, EP-GAN preserves performance when provided with incomplete membrane potential responses up to 25% and steady-state current profiles up to 75%. EP-GAN is designed to leverage the generative capability of GAN to align with the dynamical structure of HH-model, and thus able to achieve such performance.

### Competing Interest Statement

The authors have declared no competing interest.

ElectroPhysiomeGAN: Generation of Biophysical Neuron Model Parameters from Recorded Electrophysiological Responses

c-elegans神経系のバイオフィジカルニューロンモデルパラメータを記録された電気生理学的応答から生成するelectrophysiomegan


C. elegans神経系のバイオフィジカルニューロンモデルパラメータを記録された電気生理学的応答から生成するElectroPhysiomeGAN
