
Inhibitory GABA levels in the visual cortex region MT+, coupled with functional connectivity between MT+ and frontal cortex, mediate the performance in visuo-spatial intelligence tasks.


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The canonical theory emphasizes fronto-parietal network (FPN) is key in mediating general fluid intelligence (gF). Meanwhile, recent studies show that multiple sensory regions in occipito-temporal border also play a key role in gF. However, the underlying mechanism is not yet clear. To investigate this issue, this study selects human MT complex (MT+), a region locates at the occipito-temporal border representing multiple sensory flows as a target brain area. Using ultra-high field magnetic resonance spectroscopy (MRS) to measure GABA/glutamate concentrations in MT+ combining resting-state fMRI functional connectivity (FC), behavioral examinations including MT+ perception suppression test and gF subtest in visuo-spatial component, we reveal that MT+ GABA and frontal-MT+ FC significantly correlate with the performance of visuo-spatial intelligence. Further, serial mediation model demonstrates that MT+ GABA predicting visuo-spatial g F fully mediated by reverberation effect between frontal and MT+ network. Our finding highlights that sensory cortex could integrate into complex cognition system as an intellectual hub.

### Competing Interest Statement

The authors have declared no competing interest.

GABA-ergic inhibition in human MT predicts visuo-spatial intelligence mediated by reverberation with frontal cortex

inhibitory-mechanisms-in-visual-cortex-mediate-visuo-spatial-intelligence


Inhibitory Mechanisms in Visual Cortex Mediate Visuo-Spatial Intelligence
