
Photobiocatalysis enables the stereoselective synthesis of a range of α-tri- and tetrasubstituted non-canonical amino acids through cooperative use of engineered pyridoxal biocatalysts, photoredox catalysts, and an oxidizing agent.


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We report on the oxidative&nbsp;cross-coupling of organoboron reagents and amino acids via pyridoxal biocatalysis to produce non-canonical amino acids, uncovering stereoselective, intermolecular free-radical transformations.

Stereoselective amino acid synthesis by photobiocatalytic oxidative coupling - Nature

stereoselective-synthesis-of-non-canonical-amino-acids-via-photobiocatalytic-oxidative-coupling


Stereoselective Synthesis of Non-Canonical Amino Acids via Photobiocatalytic Oxidative Coupling
