An Intestinal Pathway Involving the Sirtuin SIR-2.1, Heat Shock Factor HSF-1, and Adipose Triglyceride Lipase ATGL-1 Regulates Lipolysis in C. elegans
The sirtuin SIR-2.1 activates lipolysis during starvation by suspending the HSF-1-mediated repression of the adipose triglyceride lipase ATGL-1 in the C. elegans intestine.