Основні поняття
The dopamine receptor Dop1R2 is required in the α/β-lobes and α'/β'-lobes of the Drosophila mushroom body for later stages of aversive and appetitive memory formation, but is dispensable for short-term memory.
Анотація
The content discusses the role of the dopamine receptor Dop1R2 in memory formation in Drosophila. The authors generated a conditional knockout line for Dop1R2 to study its function in a spatiotemporal manner.
Key highlights:
- Dop1R2 is expressed in the mushroom body (MB) of the fly brain, a region crucial for olfactory learning and memory.
- Knocking out Dop1R2 in the whole MB or specifically in the α/β-lobes and α'/β'-lobes impairs 2-hour aversive and appetitive memory, as well as 24-hour appetitive long-term memory, but does not affect short-term memory.
- Dop1R2 is dispensable for memory formation in the γ-lobe of the MB.
- Dop1R2 likely acts through the cAMP/PKA and Ca2+ signaling pathways to regulate later stages of memory consolidation and maintenance, potentially by modulating the activity of mushroom body output neurons.
- The results highlight the spatially and temporally restricted role of the dopamine receptor Dop1R2 in the complex process of memory formation.
Статистика
Dop1R2 is required in the α/β-lobes and α'/β'-lobes, but not the γ-lobe, of the mushroom body for 2-hour aversive and appetitive memory, as well as 24-hour appetitive long-term memory.
Цитати
"Loss of Dop1R2 in the α/β-lobes (Figure 3C) or the α'/β'-lobes (Figure 3D) impaired 2h memory after aversive training."
"Flipping out Dop1R2 in the whole MB (Figure 3E) results in a reduced performance score for 2h reward memory."
"Flipping out dop1R2 in the whole MB causes a reduced 24h memory performance (Figure 4A)."