
Chemists have achieved a diastereoselective and enantioselective synthesis of the valuable natural product (−)-ambrox and (+)-sclareolide through a catalytic asymmetric polyene cyclization using a highly Brønsted-acidic and confined imidodiphosphorimidate catalyst in the presence of fluorinated alcohols.


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The catalytic asymmetric polyene cyclization of homofarnesol to ambrox is achieved using a highly Brønsted-acidic and confined imidodiphosphorimidate catalyst.

The catalytic asymmetric polyene cyclization of homofarnesol to ambrox - Nature

catalytic-asymmetric-polyene-cyclization-of-homofarnesol-to-ambrox-a-challenging-synthetic-transformation-achieved


Catalytic Asymmetric Polyene Cyclization of Homofarnesol to Ambrox: A Challenging Synthetic Transformation Achieved
